Early detection and early intervention are crucial to the prevention and treatment of tumors
In 2020, there will be 19.3 million new cancer cases and 10 million deaths worldwide, which is 2.3 times that of COVID-19. Compared with European and American countries, many tumors are found in the advanced stage in China, and an important factor is that the popularization of early tumor detection is far from enough.
DNA methylation is one of the most important epigenetic regulation methods. DNA methylation can change the genetic expression without changing the DNA sequence. Abnormal promoter methylation is a frequent early event in the occurrence of many tumors, so the methylation status of tumor-related genes is an early sensitive indicator of tumor occurrence and is considered as a promising tumor molecular biomarker.
Blood Methylation
Blood methylation
Tumor cell necrosis or apoptosis will release fragmented circulating free DNA (ctDNA) carrying genetic information and epigenetic changes into peripheral blood.Methylation of ctDNA is an important signal for early diagnosis, recurrence monitoring and prognosis judgment of tumor.
The detection of ctDNA methylation has become the mainstream detection technology in the field of early screening because of its high stability and tissue specificity, and it is also a valuable marker in tumor liquid biopsy.
Tumor cell necrosis or apoptosis will release fragmented circulating free DNA (ctDNA) carrying genetic information and epigenetic changes into peripheral blood. Methylation of ctDNA is an important signal for early diagnosis, recurrence monitoring and prognosis judgment of tumor. The detection of ctDNA methylation has become the mainstream detection technology in the field of early screening because of its high stability and tissue specificity, and it is also a valuable marker in tumor liquid biopsy.
Fecal Methylation
Fecal methylation
Feces are a promising sample for detecting gastrointestinal cancer. Due to metabolism, epithelial cells in the gastrointestinal tract will fall off continuously, and the proportion of tumor cells shedding is higher than that of normal epithelial cells，By collecting feces and separating and extracting DNA from gastrointestinal tumor cells, we can detect whether there is specific methylation related to cancer.
Feces are a promising sample for detecting gastrointestinal cancer. Due to metabolism, epithelial cells in the gastrointestinal tract will fall off continuously, and the proportion of tumor cells shedding is higher than that of normal epithelial cells，By collecting feces and separating and extracting DNA from gastrointestinal tumor cells, we can detect whether there is specific methylation related to cancer.
